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基于DNA适配体的荧光生物传感器

董亚非 胡文晓 钱梦瑶 王越

董亚非, 胡文晓, 钱梦瑶, 王越. 基于DNA适配体的荧光生物传感器[J]. 电子与信息学报, 2020, 42(6): 1374-1382. doi: 10.11999/JEIT190860
引用本文: 董亚非, 胡文晓, 钱梦瑶, 王越. 基于DNA适配体的荧光生物传感器[J]. 电子与信息学报, 2020, 42(6): 1374-1382. doi: 10.11999/JEIT190860
Yafei DONG, Wenxiao HU, Mengyao QIAN, Yue WANG. DNA Aptamer-based Fluorescence Biosensor[J]. Journal of Electronics and Information Technology, 2020, 42(6): 1374-1382. doi: 10.11999/JEIT190860
Citation: Yafei DONG, Wenxiao HU, Mengyao QIAN, Yue WANG. DNA Aptamer-based Fluorescence Biosensor[J]. Journal of Electronics and Information Technology, 2020, 42(6): 1374-1382. doi: 10.11999/JEIT190860

基于DNA适配体的荧光生物传感器

doi: 10.11999/JEIT190860
基金项目: 国家自然科学基金(61572302),陕西省自然科学基础研究计划(2020JM-298)
详细信息
    作者简介:

    董亚非:男,1963年,教授,研究方向为DNA计算和生物传感器

    胡文晓:女,1996年,硕士生,研究方向为DNA计算和生物传感器

    钱梦瑶:女,1995年,硕士生,研究方向为DNA计算和生物传感器

    王越:女,1995年,硕士生,研究方向为DNA计算和生物传感器

    通讯作者:

    董亚非 dongyf@snnu.edu.cn

  • 中图分类号: TP212.3

DNA Aptamer-based Fluorescence Biosensor

Funds: The National Natural Science Foundation of China (61572302), The Natural Science Basic Research Plan in Shaanxi Province of China (2020JM-298)
  • 摘要: 近年来,随着DNA纳米技术的飞速发展,基于DNA作为适配体的荧光生物传感器不断被大量学者研究和构建,以实现对靶标物质的灵敏快速检测。作为DNA纳米技术的新兴方向,基于DNA适配体的荧光生物传感器具有巨大的应用潜力。该文对近年来基于DNA适配体所构建的荧光生物传感器进行了总结。包括荧光信号的实现:荧光染料标记;非荧光染料标记。荧光检测信号的提升:酶介导的靶标循环和信号扩增策略;链置换反应介导的靶标循环和信号扩增策略;基于链置换反应和酶介导的靶标循环和信号扩增策略。在此基础上对基于DNA适配体的荧光生物传感器进行展望并提出建议。
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    出版历程
    • 收稿日期:  2019-11-01
    • 修回日期:  2020-03-14
    • 网络出版日期:  2020-04-03
    • 刊出日期:  2020-06-22

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